Chapter III

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

D70 Agranulocytosis
Agranulocytic angina
Infantile genetic agranulocytosis
Kostmann's disease
· congenital
· cyclic
· drug-induced
· periodic
· splenic (primary)
· toxic
Neutropenic splenomegaly
Use additional external cause code (Chapter XX), if desired, to identify drug, if drug-induced.
Excludes: transient neonatal neutropenia ( P61.5 )

D71 Functional disorders of polymorphonuclear neutrophils
Cell membrane receptor complex [CR3] defect
Chronic (childhood) granulomatous disease
Congenital dysphagocytosis
Progressive septic granulomatosis

D72 Other disorders of white blood cells
Excludes: basophilia ( D75.8 )
immunity disorders ( D80-D89 )
neutropenia ( D70 )
preleukaemia (syndrome) ( D46.9 )
D72.0 Genetic anomalies of leukocytes
Anomaly (granulation)(granulocyte) or syndrome:
· Alder
· May-Hegglin
· Pelger-Huët
· leukocytic:
  · hypersegmentation
  · hyposegmentation
· leukomelanopathy
Excludes: Chediak(-Steinbrinck)-Higashi syndrome ( E70.3 )
D72.1 Eosinophilia
· allergic
· hereditary
D72.8 Other specified disorders of white blood cells
Leukaemoid reaction:
· lymphocytic
· monocytic
· myelocytic
Lymphocytosis (symptomatic)
Monocytosis (symptomatic)
D72.9 Disorder of white blood cells, unspecified

D73 Diseases of spleen
D73.0 Hyposplenism
Asplenia, postsurgical
Atrophy of spleen
Excludes: asplenia (congenital) ( Q89.0 )
D73.1 Hypersplenism
Excludes: splenomegaly:
· NOS ( R16.1 )
· congenital ( Q89.0 )
D73.2 Chronic congestive splenomegaly
D73.3 Abscess of spleen
D73.4 Cyst of spleen
D73.5 Infarction of spleen
Splenic rupture, nontraumatic
Torsion of spleen
Excludes: traumatic rupture of spleen ( S36.0 )
D73.8 Other diseases of spleen
Fibrosis of spleen NOS
Splenitis NOS
D73.9 Disease of spleen, unspecified

D74 Methaemoglobinaemia
D74.0 Congenital methaemoglobinaemia
Congenital NADH-methaemoglobin reductase deficiency
Haemoglobin-M [Hb-M] disease
Methaemoglobinaemia, hereditary
D74.8 Other methaemoglobinaemias
Acquired methaemoglobinaemia (with sulfhaemoglobinaemia)
Toxic methaemoglobinaemia
Use additional external cause code (Chapter XX), if desired, to identify cause.
D74.9 Methaemoglobinaemia, unspecified

D75 Other diseases of blood and blood-forming organs
Excludes: enlarged lymph nodes ( R59.- )
hypergammaglobulinaemia NOS ( D89.2 )
· NOS ( I88.9 )
· acute ( L04.- )
· chronic ( I88.1 )
· mesenteric (acute)(chronic) ( I88.0 )
D75.0 Familial erythrocytosis
· benign
· familial
Excludes: hereditary ovalocytosis ( D58.1 )
D75.1 Secondary polycythaemia
Erythrocytosis NOS
· acquired
· due to:
  · erythropoietin
  · fall in plasma volume
  · high altitude
  · stress
· emotional
· hypoxaemic
· nephrogenous
· relative
· tumour
Excludes: polycythaemia:
· neonatorum ( P61.1 )
· vera ( D45 )
D75.2 Essential thrombocytosis
Excludes: essential (haemorrhagic) thrombocythaemia ( D47.3 )
D75.8 Other specified diseases of blood and blood-forming organs
D75.9 Disease of blood and blood-forming organs, unspecified

D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
Excludes: Letterer-Siwe disease ( C96.0 )
malignant histiocytosis ( C96.1 )
reticuloendotheliosis or reticulosis:
· histiocytic medullary ( C96.1 )
· leukaemic ( C91.4 )
· lipomelanotic ( I89.8 )
· malignant ( C85.7 )
· nonlipid ( C96.0 )
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
Eosinophilic granuloma
Hand-Schüller-Christian disease
Histiocytosis X (chronic)
D76.1 Haemophagocytic lymphohistiocytosis
Familial haemophagocytic reticulosis
Histiocytoses of mononuclear phagocytes other than Langerhans' cells NOS
D76.2 Haemophagocytic syndrome, infection-associated
Use additional code, if desired, to identify infectious agent or disease.
D76.3 Other histiocytosis syndromes
Reticulohistiocytoma (giant-cell)
Sinus histiocytosis with massive lymphadenopathy

D77* Other disorders of blood and blood-forming organs in diseases classified elsewhere
Fibrosis of spleen in schistosomiasis [bilharziasis] ( B65.-+ )